MovDisordV3, Main, Exploration, bibRecord, 003E53

Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease

Identifieur interne : 003E53 ( Main/Exploration ); précédent : 003E52; suivant : 003E54

Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease

Auteurs : Adrian P. Fawcett [Canada] ; Ilena Moro [Canada] ; Anthony E. Lang [Canada] ; Andres M. Lozano [Canada] ; William D. Hutchison [Canada]

Source :

Movement disorders [ 0885-3185 ] ; 2004.

RBID : Pascal:05-0222398

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Noyau gris central, Mouvement oculaire, Chorée Huntington, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Basal ganglion, Deep brain stimulation, Eye movement, Huntington disease, Nervous system diseases.

Abstract

Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is being evaluated as a potential new therapy for patients with Huntington's disease (HD). In addition to skeletal movement disorders, HD patients have difficulty initiating voluntary saccades and have difficulty in suppressing rapid saccades toward newly appearing stimuli. We measured several saccade parameters in an HD patient who had marked improvement of clinical symptoms with bilateral GPi DBS to determine whether oculomotor performance improved in parallel with clinical scores. Oculomotor performance was assessed using three testing paradigms: pro-saccades, anti-saccades, and memory-guided saccades. The data from the HD patient was also compared to that of two healthy controls. Pallidal DBS decreased pro-saccade latency, total movement time, and the number of correctly executed trials, as well as increasing saccade gain. Memory-saccade performance was negatively affected with stimulation: saccade gain decreased, latency increased, and the patient's ability to suppress unwanted saccades decreased with stimulation. Our data demonstrate a task-specific improvement of oculomotor deficits in this HD patient with pallidal DBS, supporting a role of GPi in oculomotor control.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is being evaluated as a potential new therapy for patients with Huntington's disease (HD). In addition to skeletal movement disorders, HD patients have difficulty initiating voluntary saccades and have difficulty in suppressing rapid saccades toward newly appearing stimuli. We measured several saccade parameters in an HD patient who had marked improvement of clinical symptoms with bilateral GPi DBS to determine whether oculomotor performance improved in parallel with clinical scores. Oculomotor performance was assessed using three testing paradigms: pro-saccades, anti-saccades, and memory-guided saccades. The data from the HD patient was also compared to that of two healthy controls. Pallidal DBS decreased pro-saccade latency, total movement time, and the number of correctly executed trials, as well as increasing saccade gain. Memory-saccade performance was negatively affected with stimulation: saccade gain decreased, latency increased, and the patient's ability to suppress unwanted saccades decreased with stimulation. Our data demonstrate a task-specific improvement of oculomotor deficits in this HD patient with pallidal DBS, supporting a role of GPi in oculomotor control.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease

Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri